Altered fractalkine cleavage potentially promotes local inflammation in NOD salivary gland
2008
Fractalkine Cleavage and Inflammation in NOD Mice
Sample size: 14
publication
Evidence: moderate
Author Information
Author(s): Wildenberg Manon E, van Helden-Meeuwsen Cornelia G, Drexhage Hemmo A, Versnel Marjan A
Primary Institution: Erasmus MC
Hypothesis
Altered fractalkine cleavage promotes local inflammation in the salivary glands of NOD mice.
Conclusion
Aberrant proteolytic activity in the NOD salivary gland results in increased fractalkine cleavage, which may contribute to autoimmunity.
Supporting Evidence
- Fractalkine was detected in salivary glands of both NOD and control mice at all ages.
- NOD mice exhibited significantly more antibodies against fractalkine than did control animals.
- Increased gelatinase and α-secretase activity were detected in NOD SMG.
Takeaway
In mice with a specific disease, a protein called fractalkine gets cut up in a way that might make the body attack itself, leading to inflammation.
Methodology
Protein expression was studied using Western blot analysis and protease activity was measured in salivary gland tissue lysates.
Participant Demographics
Female NOD/LTj mice aged 5 to 25 weeks were used.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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