Comparison of Haplotype Similarity Measures
Author Information
Author(s): Vivien Marquard, Lars Beckmann, Justo L Bermejo, Christine Fischer, Jenny Chang-Claude
Primary Institution: German Cancer Research Center DKFZ
Hypothesis
Do alternative haplotype similarity measures improve the power of haplotype-sharing analysis?
Conclusion
The alternative haplotype similarity measures, except Yu's measure, are not superior to the simplest measure based on the number of intervals flanked by markers.
Supporting Evidence
- All methods showed a very high power of comparable magnitude for chromosome 6.
- For chromosome 18, power ranged from 19% to 99% at the pointwise 5% significance level.
- Yu's measure had lower power compared to other methods for chromosome 18.
Takeaway
This study looked at different ways to compare genetic similarities to see which method works best for finding disease-related genes.
Methodology
The study used simulated data sets from a case-control design to analyze haplotype similarities using various measures.
Potential Biases
Potential biases may arise from the assumptions made in estimating genetic distances.
Limitations
The study focused on specific genomic regions and may not generalize to all genetic contexts.
Participant Demographics
1500 families with two affected children and 2000 unrelated controls.
Statistical Information
Statistical Significance
p<0.05
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