ZINC (II) COMPLEXES A NEW GROUP OF NON-MUTAGENIC HERPES SIMPLEX VIRUS INHIBITORS
2000
Zinc Complexes as Non-Mutagenic Herpes Virus Inhibitors
publication
Evidence: moderate
Author Information
Author(s): Margarita Pesheva, Tatiana Varadinova
Primary Institution: Sofia University
Hypothesis
Do Zn(II) complexes with picolinic and aspartic acids express mutagenic effects?
Conclusion
Zn(pie)2 and Zn(asp)2 do not show mutagenic effects in tested prokaryotic and eukaryotic systems.
Supporting Evidence
- Zn(pie)2 and Zn(asp)2 do not induce frameshift mutations in Salmonella typhimurium.
- Zn(asp)2 showed a weak mutagenic effect in eukaryotic S. cerevisiae strain PV3.
- Both zinc complexes did not induce reversion in the his7-1 locus.
Takeaway
Zinc compounds can help fight a virus without causing mutations in cells.
Methodology
The mutagenicity of Zn(asp)2 and Zn(pic)2 was evaluated using prokaryotic and eukaryotic test systems.
Limitations
The study only tested specific strains and concentrations of zinc complexes.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website