Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer
2001
KLK5 Expression and Ovarian Cancer Prognosis
Sample size: 142
publication
Evidence: moderate
Author Information
Author(s): Kim H, Scorilas A, Katsaros D, Yousef G M, Massobrio M, Fracchioli S, Piccinno R, Gordini G, Diamandis E P
Primary Institution: Mount Sinai Hospital
Hypothesis
KLK5 may be a new prognostic indicator in ovarian cancer.
Conclusion
KLK5 expression is associated with more aggressive forms of epithelial ovarian carcinoma and has independent prognostic value in low grade tumours.
Supporting Evidence
- KLK5 was found to be highly expressed in 41% of ovarian cancer samples.
- There was a strong positive relation between KLK5 expression and tumour grade.
- Patients with KLK5 positive tumours had an increased risk for relapse and death.
Takeaway
Researchers found that a gene called KLK5 is linked to worse outcomes in ovarian cancer, especially in less severe cases.
Methodology
The study examined KLK5 mRNA expression in 142 malignant ovarian tissues using RT-PCR and PCR amplification.
Statistical Information
P-Value
P = 0.006, P = 0.027, P = 0.018, P = 0.022
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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