Sindbis Virus Infection in Birds and Humans in Finland
Author Information
Author(s): Kurkela Satu, Rätti Osmo, Huhtamo Eili, Uzcátegui Nathalie Y., Nuorti J. Pekka, Laakkonen Juha, Manni Tytti, Helle Pekka, Vaheri Antti, Vapalahti Olli
Primary Institution: Haartman Institute at the University of Helsinki
Hypothesis
Migratory birds have carried the virus to northern Europe.
Conclusion
Grouse may be involved in the epidemiology of Sindbis virus in humans.
Supporting Evidence
- SINV antibodies were found in 27.4% of resident grouse in 2003, a year after a human outbreak.
- Seroprevalence in humans was highest in North Karelia at 5.2%.
- Only 1.4% of grouse were seropositive in 2004, indicating a significant decline.
Takeaway
This study found that some birds can carry a virus that makes people sick, and it looks like grouse might help spread it.
Methodology
The study tested blood samples from humans and birds for Sindbis virus antibodies using various serological methods.
Potential Biases
Potential underdiagnosis of cases in certain demographics.
Limitations
The human sample was not random and was based on treatment location, which may not represent the entire population.
Participant Demographics
The study included 2,529 human specimens with a higher seroprevalence in men and older age groups.
Statistical Information
P-Value
p<0.030
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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