Plasma Protein Biomarkers and Cognitive Performance in Women with HIV
Author Information
Author(s): Li Wei, Wang Ge, Vance David, Li Daniel
Primary Institution: University of Alabama at Birmingham
Hypothesis
This study aimed to investigate the association between plasma proteomic signatures and cognition in virologically well-controlled women with HIV.
Conclusion
A panel of plasma protein biomarkers can potentially predict cognitive function in women living with HIV.
Supporting Evidence
- Certain plasma proteins are linked to attention and memory in women with HIV.
- Some proteins are positively associated with executive function.
- Multiple signaling networks may explain cognitive functioning in women living with HIV.
Takeaway
Scientists studied blood proteins in women with HIV to see how they affect thinking skills, and found some proteins might help predict how well they think.
Methodology
Seventy-seven women completed neuropsychological testing and blood draws, with protein biomarkers analyzed using a multiplexing method and random forest analysis.
Participant Demographics
Women living with HIV from three Women’s Interagency HIV Study sites.
Digital Object Identifier (DOI)
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