Effects of a Dietary Supplement on Hormone Levels in Healthy Males
Author Information
Author(s): Angwafor Fru III, Anderson Mark L
Primary Institution: Yaounde Teaching Hospital, University of Yaounde, Cameroon
Hypothesis
A precise combination of astaxanthin and saw palmetto will regulate the inhibitory activity of both 5α-reductase and aromatase enzymes in vivo, leading to decreased DHT and estradiol levels and increased testosterone levels in a dose-dependent manner.
Conclusion
The dietary supplement Alphastat® significantly increased testosterone and decreased dihydrotestosterone levels in healthy males, but the effects were not dose-dependent.
Supporting Evidence
- Both dose groups showed significant increases in testosterone levels.
- Dihydrotestosterone levels decreased significantly in both dose groups.
- Estradiol levels decreased significantly in the 2000 mg/day dose group.
Takeaway
This study tested a supplement that helps men keep their testosterone levels up while lowering another hormone called DHT, which can cause problems as they age.
Methodology
42 healthy males aged 37 to 70 were divided into two groups and dosed with either 800 mg/day or 2000 mg/day of the supplement for 14 days, with blood samples collected to measure hormone levels.
Potential Biases
Potential bias due to funding from the supplement manufacturer.
Limitations
The study did not include a control group and the sample size was limited to healthy males aged 37 to 70.
Participant Demographics
Healthy males aged 37 to 70, with an average age of 55.6 years in the 800 mg group and 61 years in the 2000 mg group.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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