SGNP: An Essential Stress Granule/Nucleolar Protein Potentially Involved in 5.8s rRNA Processing/Transport
2008
SGNP: A Key Protein in Stress Granules and Nucleolus Function
publication
Evidence: moderate
Author Information
Author(s): Zhu Chun-Hong, Kim Jinyong, Wright Jerry W., Woodring E.
Primary Institution: Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Hypothesis
Is SGNP involved in ribosomal biogenesis and translational control in response to oxidative stress?
Conclusion
SGNP is essential for ribosomal biogenesis and translational control during oxidative stress.
Supporting Evidence
- SGNP localization changes under oxidative stress, moving from the nucleolus to stress granules.
- Knockdown of SGNP leads to increased protein synthesis and cell death.
- SGNP is involved in the processing of 5.8S rRNA, which is crucial for ribosomal function.
Takeaway
SGNP is a protein that helps cells deal with stress by managing how they make proteins and process RNA.
Methodology
A genetic screen was used to identify SGNP, followed by RT-PCR and localization studies under oxidative stress conditions.
Digital Object Identifier (DOI)
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