Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2
2008
How Hypoxia Affects Endosialin Expression
publication
Evidence: moderate
Author Information
Author(s): Ohradanova A, Gradin K, Barathova M, Zatovicova M, Holotnakova T, Kopacek J, Parkkila S, Poellinger L, Pastorekova S, Pastorek J
Primary Institution: Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences
Hypothesis
Hypoxia regulates endosialin expression via HIF-2.
Conclusion
The study shows that hypoxia induces endosialin gene transcription primarily through HIF-2.
Supporting Evidence
- Hypoxia increases endosialin expression in human cell lines.
- HIF-2 is primarily responsible for the hypoxic induction of endosialin.
- Endosialin expression is linked to angiogenesis in tumors.
Takeaway
When there isn't enough oxygen, a protein called HIF-2 helps increase the amount of endosialin, which is important for blood vessel growth in tumors.
Methodology
The study used cell culture experiments to analyze the effects of hypoxia on endosialin expression in various cell lines.
Digital Object Identifier (DOI)
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