Safety and Toxicological Evaluation of Synthetic Vitamin K2 (Menaquinone-7)
Author Information
Author(s): Pucaj Kresimir, Rasmussen Henrik, Moller Mona, Preston Tom
Primary Institution: Kappa Bioscience AS, Oslo, Norway
Hypothesis
The study aims to determine the safety and potential toxicity of synthetic menaquinone-7 (MK-7) in animal models.
Conclusion
Synthetic MK-7 is of low acute toxicity and does not produce adverse effects in Sprague-Dawley rats at doses up to 10 mg/kg body weight/day.
Supporting Evidence
- MK-7 did not induce any signs of toxicity in treated mice at the limit dose level of 2000 mg/kg body weight.
- All animals in the 90-day study survived with no clinical signs of systemic toxicity.
- The NOAEL for MK-7 in Sprague-Dawley rats was determined to be 10 mg/kg body weight/day.
Takeaway
This study found that a synthetic form of vitamin K2 is safe for use, even in high doses, without causing harm to animals.
Methodology
The study involved acute oral toxicity tests in mice and a 90-day subchronic toxicity study in rats, with various doses administered and monitored for adverse effects.
Limitations
The study was conducted only in animal models, and results may not directly translate to humans.
Participant Demographics
The study involved female BomTac:NMRI mice and Sprague-Dawley rats, aged 4-5 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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