Significance of p-c-Jun, TCF4, and beta-Catenin in Colorectal Tumors
Author Information
Author(s): Takeda Kayoko, Kinoshita Ichiro, Shimizu Yasushi, Ohba Yusuke, Itoh Tomoo, Matsuno Yoshihiro, Shichinohe Toshiaki, Dosaka-Akita Hirotoshi
Primary Institution: Hokkaido University Graduate School of Medicine
Hypothesis
The study aims to determine the significance of p-c-Jun, TCF4, and beta-Catenin in human colorectal tumors.
Conclusion
The study suggests that p-c-Jun, TCF4, and beta-Catenin play important roles in the development of human colorectal tumors, with p-c-Jun being particularly significant in the earlier stages.
Supporting Evidence
- Expression of p-c-Jun, TCF4, and beta-Catenin was significantly higher in adenomas than in adjacent normal epithelia.
- p-c-Jun expression was negatively correlated with pT stage progression in adenocarcinomas.
- Significant correlations were observed between p-c-Jun and TCF4, TCF4 and beta-Catenin, and p-c-Jun and MMP7.
Takeaway
This study looked at proteins in colorectal tumors and found that some proteins are more active in early tumor stages, which might help us understand how these tumors grow.
Methodology
The study analyzed nuclear expression of p-c-Jun, TCF4, and beta-Catenin in 68 resected colorectal tumors using immunohistochemistry.
Participant Demographics
The participants included 35 men and 33 women with an average age of 63.8 years.
Statistical Information
P-Value
0.0006
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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