Impact of PCSK1 Variants on Body Fat and Glucose Metabolism
Author Information
Author(s): Gjesing Anette P., Vestmar Marie A., Jørgensen Torben, Heni Martin, Holst Jens J., Witte Daniel R., Hansen Torben, Pedersen Oluf
Primary Institution: Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
Hypothesis
The study aimed to evaluate the effects of the G-allele of rs6232 and the C-allele of rs6235 within PCSK1 on measures of body fat and glucose homeostasis in Danish individuals.
Conclusion
PCSK1 variants rs6232 and rs6235 affect body composition and glucose metabolism, with effects modified by sex and glucose tolerance status.
Supporting Evidence
- The rs6235 C-allele was associated with an increased waist circumference of 0.8 cm per allele.
- The rs6232 G-allele was associated with higher levels of GLP-1, GLP-2, and glucagon.
- Meta-analyses showed significant associations of PCSK1 variants with metabolic traits.
- Interactions with sex were significant for the rs6235 C-allele regarding waist circumference.
Takeaway
This study looked at how certain gene variations affect body fat and blood sugar levels, finding that these effects can change based on a person's sex and how well they process sugar.
Methodology
The study involved genotyping PCSK1 variants in 6,164 Danish individuals and conducting meta-analyses with additional data from 27,786 individuals.
Potential Biases
Potential biases may arise from the selection of participants and the specific population studied.
Limitations
The study's findings may not be generalizable beyond the Danish population and were limited to treatment-naïve individuals.
Participant Demographics
The study included middle-aged Danish individuals, with a focus on glucose tolerance status.
Statistical Information
P-Value
p=0.008 for waist circumference increase per C-allele
Confidence Interval
0.2–1.5 for waist circumference increase per C-allele
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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