Vasorelaxant and Antioxidant Activities of Spilanthes acmella Murr.
Author Information
Author(s): Wongsawatkul Orapin, Prachayasittikul Supaluk, Isarankura-Na-Ayudhya Chartchalerm, Satayavivad Jutamaad, Ruchirawat Somsak, Prachayasittikul Virapong
Primary Institution: Srinakharinwirot University
Hypothesis
What are the effects of Spilanthes acmella Murr. extracts on vascular function and antioxidant activity?
Conclusion
Spilanthes acmella Murr. extracts exhibit vasorelaxant and antioxidant activities, with the ethyl acetate extract being the most potent.
Supporting Evidence
- The extracts showed maximal vasorelaxations in a dose-dependent manner.
- The ethyl acetate extract had an ED50 of 76.1 ng/mL, indicating high potency.
- The chloroform extract exhibited the highest vasorelaxation and antioxidant activity.
- Vasorelaxation was abolished upon removal of endothelial cells, confirming the role of NO.
- All extracts demonstrated antioxidant activity in DPPH and SOD assays.
Takeaway
This study shows that a plant called Spilanthes acmella can help relax blood vessels and fight off harmful substances in the body.
Methodology
The study involved testing various extracts of Spilanthes acmella Murr. on rat thoracic aorta to measure their vasorelaxant and antioxidant effects.
Limitations
The study primarily focused on in vitro results, and further in vivo studies are needed to confirm the findings.
Participant Demographics
Male Sprague-Dawley rats (170–250 g) were used in the experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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