Efficacy of Diamidines in T. evansi Infected Goats
Author Information
Author(s): Gillingwater Kirsten, Gutierrez Carlos, Bridges Arlene, Wu Huali, Deborggraeve Stijn, Ali Ekangu Rosine, Kumar Arvind, Ismail Mohamed, Boykin David, Brun Reto
Primary Institution: Swiss Tropical and Public Health Institute, Basel, Switzerland
Hypothesis
Can novel diamidine compounds effectively cure Trypanosoma evansi infected goats?
Conclusion
Two diamidine compounds (DB 75 and DB 867) showed comparable efficacy to the standard drug diminazene at lower doses.
Supporting Evidence
- DB 75 and DB 867 showed complete curative efficacy at lower doses than the standard drug diminazene.
- DB 1192 was ineffective at both tested doses.
- Goats treated with DB 75 at 1.25 mg/kg remained negative for T. evansi for the entire follow-up period.
Takeaway
Scientists tested new medicines on sick goats to see if they could help them get better, and two of the new medicines worked really well.
Methodology
Goats were infected with T. evansi and treated with different doses of diamidine compounds, followed by monitoring for efficacy and toxicity.
Limitations
The study was limited to a specific goat population and may not be generalizable to all animals.
Participant Demographics
33 female Canarian goats, aged over six months.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website