Glutathione Deficiency and Alzheimer's Disease
Author Information
Author(s): Taffet George, Kumar Premranjan, Osahon Ob, Onyechi Chimaoge, Minard Charles, Masdeu Joseph, Sekhar Rajagopal
Primary Institution: Baylor College of Medicine
Hypothesis
Patients with Alzheimer's disease with mild cognitive impairment will have greater glutathione deficiency than older adults.
Conclusion
Alzheimer's disease with mild cognitive impairment is associated with severe glutathione deficiency.
Supporting Evidence
- Cognitive impairment in Alzheimer's disease is linked to oxidative stress and glutathione deficiency.
- GlyNAC supplementation improved glutathione levels in aged mice.
- Young adults had the highest levels of total glutathione compared to older adults and Alzheimer's patients.
Takeaway
People with Alzheimer's disease often have low levels of an important antioxidant called glutathione, and a supplement might help improve this.
Methodology
Compared intracellular red-blood cell glutathione concentrations in young adults, older adults without cognitive impairment, and patients with Alzheimer's disease and mild cognitive impairment.
Participant Demographics
32 patients with Alzheimer's disease and mild cognitive impairment, 32 older adults, and 19 young adults.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website