Staphylococcus sciuri Exfoliative Toxin C is a Necrosis-Inducer for Mammalian Cells
2011
Staphylococcus sciuri Exfoliative Toxin C Causes Cell Death
publication
Evidence: moderate
Author Information
Author(s): Li Haihua Wang, Yongqiang Ding, Lin Zheng, Shijun J.
Primary Institution: China Agricultural University
Hypothesis
Does the exfoliative toxin C from Staphylococcus sciuri induce necrosis in mammalian cells?
Conclusion
The study found that the exfoliative toxin C from Staphylococcus sciuri induces necrosis in mammalian cells and skin lesions in newborn mice.
Supporting Evidence
- Recombinant ExhC induced necrosis in multiple cell lines.
- ExhC caused skin lesions in newborn mice.
- The necrosis-inducing effect was linked to amino acids 79-128 of ExhC.
Takeaway
The toxin from a rare bacteria can make cells die and cause skin problems in baby mice.
Methodology
The study used in vitro cell cultures and newborn mice to analyze the effects of recombinant exfoliative toxin C.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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