The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable ion channel
2024
Identifying XPR1 as a New Ion Channel for Phosphate Transport
publication
Evidence: high
Author Information
Author(s): Wang Zhao, Wu Hongjiang, Sun Liang, Wensel Theodore, Horrigan Frank, Huo Tong
Hypothesis
Can XPR1 function as a voltage- and phosphate-activated ion channel?
Conclusion
The study reveals that XPR1 operates as a phosphate-permeable ion channel, crucial for phosphate transport in cells.
Supporting Evidence
- XPR1 is the only known phosphate export protein in mammals.
- Malfunctions in XPR1 are linked to diseases like brain calcification and certain cancers.
- The structure of hXPR1 is distinct from known ion transporters.
- Patch clamp recordings show that hXPR1 is voltage- and phosphate-dependent.
- Purified hXPR1 can transport phosphate when reconstituted.
Takeaway
XPR1 is a special channel in our cells that helps move phosphate in and out, which is really important for our health.
Methodology
The study used cryogenic electron microscopy, patch clamp recordings, and proteoliposomal uptake assays to analyze XPR1.
Digital Object Identifier (DOI)
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