GST Gene Polymorphisms and Asthma in Tunisian Children
Author Information
Author(s): Hanene Chelbi, Jihene Lachheb, Jamel Ammar, Kamel Hamzaoui, Agnès Hamzaoui
Primary Institution: Faculty of Medicine, University of Tunis El Manar II
Hypothesis
Are polymorphisms of GST genes associated with asthma and atopy among Tunisian children?
Conclusion
Polymorphisms within genes of the GST superfamily were associated with risk of asthma and atopy in Tunisia.
Supporting Evidence
- GSTM1 null genotype was significantly associated with increased risk of asthma.
- Asthmatic children had a higher prevalence of the GSTP1Ile105 allele than the control group.
- The GSTT1 null genotype was significantly associated with atopy.
Takeaway
This study found that certain genes related to detoxifying harmful substances are linked to asthma in children from Tunisia.
Methodology
The study involved genotyping GST gene polymorphisms in 105 asthmatic children and 112 healthy controls using multiplex PCR and PCR-RFLP.
Potential Biases
Potential bias due to the selection of participants from a specific region.
Limitations
The study is limited to a specific ethnic group and may not be generalizable to other populations.
Participant Demographics
105 asthmatic children aged 5 to 16 years and 112 control individuals aged 5 to 16 years.
Statistical Information
P-Value
0.002
Confidence Interval
95% CI 0.94–5.87
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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