Impact of Endotoxemia on Immune Responses in HIV-1 Infected Individuals
Author Information
Author(s): Bukh Anne Roslev, Melchjorsen Jesper, Offersen Rasmus, Jensen Jens Magnus Bernth, Toft Lars, Støvring Henrik, Østergaard Lars, Tolstrup Martin, Søgaard Ole Schmeltz
Primary Institution: Aarhus University Hospital Skejby, Aarhus, Denmark
Hypothesis
Is microbial translocation and inflammation associated with innate and adaptive immune responses in adults with HIV?
Conclusion
Higher serum LPS levels predict poor vaccine responses among HAART-naive HIV-infected individuals.
Supporting Evidence
- Microbial translocation and inflammatory markers were higher among HIV-infected persons than controls.
- Cytokine levels following LPS stimulation were increased in PBMCs from HAART-naive compared to HAART-treated individuals.
- High serum LPS levels predicted poor vaccine responses among HAART-naive individuals.
Takeaway
This study found that bacteria in the blood can make it harder for people with untreated HIV to respond to vaccines.
Methodology
An observational cohort study analyzing serum and PBMCs from HIV-infected and uninfected individuals.
Potential Biases
Potential biases due to the observational nature and small sample size of HAART-naive individuals.
Limitations
The study design is cross-sectional and the HAART-naive group was relatively small.
Participant Demographics
96 HIV-infected individuals (20 HAART-naive, 76 HAART-treated) and 50 healthy controls.
Statistical Information
P-Value
p<0.001 for sCD14 levels
Confidence Interval
95% CI: −4.06–−1.17 for LPS predicting antibody response
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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