Erythromycin's Effect on Colon Motility in Children
Author Information
Author(s): Venkatasubramani Narayanan, Rudolph Colin D, Sood Manu R
Primary Institution: The Children's Hospital of Wisconsin and The Medical College of Wisconsin
Hypothesis
Does intravenous erythromycin lactobionate improve colon motility in children with chronic constipation?
Conclusion
Erythromycin does not improve colon motility in children with chronic constipation.
Supporting Evidence
- Erythromycin was administered at a dose of 1 mg/kg.
- The mean area under the curve for colon contractions was significantly lower after erythromycin compared to fasting.
- All patients had normal antro-duodenal and colon motility studies.
Takeaway
The study found that giving erythromycin to kids with constipation didn't help their colon work better.
Methodology
The study used colon manometry to evaluate the effect of intravenous erythromycin on colon motility in children.
Limitations
Only a single dose of erythromycin was evaluated, and a higher dose may be necessary for a prokinetic effect.
Participant Demographics
Mean age of participants was 9.6 years, with 5 females.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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