Effect of Food on Oral Topotecan Bioavailability
Author Information
Author(s): Herben V M M, Rosing H, Huinink W W ten Bokkel, Zomeren D M van, Batchelor D, Doyle E, Beusenberg F D, Beijnen J H, Schellens J H M
Primary Institution: Slotervaart Hospital/The Netherlands Cancer Institute
Hypothesis
Does food affect the bioavailability of oral topotecan in patients with solid tumors?
Conclusion
Food intake slightly decreases the absorption rate of oral topotecan but does not affect the overall extent of absorption.
Supporting Evidence
- The study involved 18 patients with solid tumors.
- The absolute bioavailability of topotecan averaged 42 ± 13%.
- Maximal plasma concentrations of topotecan were similar with and without food.
- The time to reach maximal plasma levels was significantly longer after food intake.
- The apparent terminal half-life was significantly longer after oral administration compared to intravenous.
Takeaway
This study looked at how eating food affects a cancer medicine called topotecan. It found that while food slows down how quickly the medicine gets into the body, it doesn't change how much of it gets absorbed.
Methodology
The study used a randomized two-period cross-over design with patients receiving oral topotecan with or without food and comparing it to intravenous administration.
Participant Demographics
Patients with solid tumors
Statistical Information
P-Value
P = 0.130; P = 0.013; P < 0.001
Confidence Interval
90% CI 0.83–1.03; 90% CI 37–47%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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