Involvement of bcl-2 and p21waf1 proteins in response of human breast cancer cell clones to Tomudex
1999
How breast cancer cells respond to Tomudex
publication
Author Information
Author(s): Orlandi L, Bearzatto A, Abolafio G, De Marco C, Daidone M G, Zaffaroni N
Primary Institution: Istituto Nazionale per lo Studio e la Cura dei Tumori
Hypothesis
The study investigates the role of bcl-2 and p21waf1 proteins in the response of human breast cancer cell clones to Tomudex.
Conclusion
The study found that bcl-2 and p21waf1 proteins play a significant role in determining the sensitivity or resistance of breast cancer cells to Tomudex.
Supporting Evidence
- The MDA-bcl4 clone was three times more resistant to Tomudex than the control clone.
- The MDA-bcl7 clone showed sensitivity to Tomudex similar to the control clone.
- An apoptotic DNA peak was observed only in the MDA-bcl7 clone after Tomudex exposure.
Takeaway
This study shows that some breast cancer cells can resist a drug called Tomudex because of certain proteins they have.
Methodology
The researchers transfected a breast cancer cell line with bcl-2 gene cDNA and analyzed the resulting clones' responses to Tomudex.
Digital Object Identifier (DOI)
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