Desmoids in familial adenomatous polyposis are monoclonal proliferations
2000
Desmoids in Familial Adenomatous Polyposis Are Monoclonal Proliferations
Sample size: 25
publication
Evidence: moderate
Author Information
Author(s): Middleton S B, Frayling I M, Phillips R K S
Primary Institution: The Polyposis Registry, Imperial Cancer Research Fund Colorectal Cancer Unit, St Mark's Hospital
Hypothesis
Are desmoids in familial adenomatous polyposis neoplastic or reactive?
Conclusion
FAP-associated desmoid tumors are true neoplasms, which may influence treatment protocols.
Supporting Evidence
- Desmoids are locally aggressive tumors that occur frequently in familial adenomatous polyposis patients.
- Neoplastic proliferations are monoclonal, while reactive processes are polyclonal.
- 21 samples from nine patients were informative for the clonality assay.
Takeaway
Desmoids are a type of tumor that can occur in people with a genetic condition, and this study found that they are actually a type of cancer.
Methodology
Examined clonality of desmoid tissue samples from FAP patients using X-chromosome inactivation patterns.
Participant Demographics
11 female FAP patients
Statistical Information
Confidence Interval
66% (range 0–75%) clonal cells
Digital Object Identifier (DOI)
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