Cardiovascular-Kidney-Metabolic Index and Mortality in Critically Ill Patients
Author Information
Author(s): Qu Xiaolong, Liu Yuping, Nie Peng, Huang Lei
Primary Institution: Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Hypothesis
The study aims to validate the correlation between the CKMI during hospitalization and all-cause mortality.
Conclusion
A higher CKMI index is associated with a significant reduction in both in-hospital and ICU mortality among critically ill patients.
Supporting Evidence
- The study enrolled 1,576 patients with a male majority of 60.79%.
- In-patient and ICU mortality rates were 11.55% and 6.73%, respectively.
- Multivariate analysis showed a significant negative correlation between CKMI index and hospital death risk.
- Subgroup analysis confirmed consistent results across different patient groups.
Takeaway
The CKMI index helps doctors understand how well a patient's heart, kidneys, and metabolism are working together, which can predict if they might get better or worse in the hospital.
Methodology
The study used a retrospective analysis of the MIMIC-IV dataset, employing Cox proportional hazards models and multivariable regression analysis.
Potential Biases
Potential selection bias due to the retrospective nature of the study.
Limitations
The study is retrospective, which may introduce selection and information bias, and it did not account for the impact of underlying diseases on mortality.
Participant Demographics
Mean age of participants was 60 years, with 60.79% being male.
Statistical Information
P-Value
0.038
Confidence Interval
0.07–0.93
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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