Portable Biosensor for Prostate Cancer Biomarker Detection
Author Information
Author(s): Rajarathinam Thenmozhi, Jayaraman Sivaguru, Kim Chang-Seok, Lee Jaewon, Chang Seung-Cheol
Primary Institution: Pusan National University
Hypothesis
Can a portable amperometric biosensor effectively detect sarcosine as a biomarker for prostate cancer?
Conclusion
The developed biosensor demonstrated high sensitivity and a low detection limit for sarcosine, making it suitable for rapid prostate cancer screening.
Supporting Evidence
- The biosensor exhibited a detection limit of 0.077 μM for sarcosine.
- It showed a sensitivity of 8.09 μA mM−1 cm−2.
- The biosensor was tested with human serum and synthetic urine samples.
- The results indicated high selectivity against common interferents.
- The biosensor maintained over 72% of its initial response after four weeks.
- The calibration curve showed linearity between 1.0 and 100 μM sarcosine.
- The biosensor's performance was validated with recovery ratios over 95%.
Takeaway
This study created a small device that can quickly check for a substance in urine that might indicate prostate cancer.
Methodology
The biosensor was developed using a chitosan-polyaniline-mesoporous carbon nanocomposite and tested for sarcosine detection in human serum and urine.
Limitations
The biosensor's performance may be affected by the presence of interfering substances in complex biological samples.
Statistical Information
P-Value
0.077
Confidence Interval
95.0%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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