New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells
2001
New cancer-fighting compounds show promise
publication
Evidence: moderate
Author Information
Author(s): Alonso M M, Encío I, Martínez-Merino V, Gil M, Migliaccio M
Primary Institution: Public University of Navarra
Hypothesis
Can benzo(b)thiophenesulfonamide derivatives inhibit NADH oxidase in tumor cells?
Conclusion
Certain benzo(b)thiophenesulfonamide derivatives can effectively inhibit a specific enzyme in leukemia cells, showing potential as cancer treatments.
Supporting Evidence
- Several benzo(b)thiophenesulfonamide derivatives were synthesized as potential cancer drugs.
- Some of these compounds showed cytotoxic activity against leukemia cells.
- The active compounds inhibited a specific NADH oxidase in the plasma membrane of the tumor cells.
Takeaway
Some new drugs made from a special chemical can help fight cancer by stopping a bad enzyme in sick cells.
Methodology
The study involved designing and synthesizing benzo(b)thiophenesulfonamide derivatives and testing their effects on leukemia cells in vitro.
Digital Object Identifier (DOI)
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