Identification of patients at risk for early death after conventional chemotherapy in solid tumours and lymphomas

2001

Identifying Patients at Risk for Early Death After Chemotherapy

Sample size: 1051 publication Evidence: moderate

Author Information

Author(s): Ray-Coquard I, Ghesquière H, Bachelot T, Borg C, Biron P, Sebban C, LeCesne A, Chauvin F, Blay J-Y

Primary Institution: Centre Léon Bérard, Lyon, France

The study aims to establish a risk model for early death after chemotherapy applicable to all tumor types.

Poor performance status and lymphopenia identify a subgroup of patients at high risk for early death after chemotherapy.

1–5% of cancer patients treated with cytotoxic chemotherapy die within a month after treatment.
In the CLB-1996 series, 43 patients (4.1%) experienced early death.
Age > 60 and performance status > 1 were significantly correlated to the risk of early death.
The calculated probability of early death was 20% in patients with both risk factors.

Some cancer patients can die soon after chemotherapy, and this study helps find out who is at risk.

The study used logistic regression to analyze risk factors in a cohort of cancer patients receiving chemotherapy.

Cancer patients receiving first course of chemotherapy, including those with aggressive non-Hodgkin's lymphoma and metastatic breast cancer.

95% Cl 10–31

p ≤ 0.01

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