Impact of Multiple Oestrogen Receptor Assays on Breast Cancer Management
Author Information
Author(s): L. Castagnetta, A. Traina, A. Di Carlo, G. Carruba, M. Lo Casto, M. Mesiti, R. Leake
Primary Institution: University of Palermo-Policlinico
Hypothesis
Do multiple oestrogen receptor assays provide significant additional information for managing breast cancer?
Conclusion
Multiple oestrogen receptor assays reveal significant differences in patient outcomes, suggesting they are more informative than single assays.
Supporting Evidence
- Patients with uniformly receptor positive primary tumours had better survival rates compared to those with uniformly receptor negative tumours.
- Out of 53 node-positive patients, 77% were already at advanced stages (T3-4).
- Only 36% of patients had tumours classified as hormone sensitive after multiple biopsies.
Takeaway
This study shows that checking hormone receptors in several parts of a breast tumor can help doctors understand how to treat cancer better.
Methodology
The study involved 101 breast cancer patients who underwent multiple biopsies to measure oestrogen receptor content and were followed for an average of 85 months.
Participant Demographics
Patients included both pre-menopausal and post-menopausal women, with a mix of node-positive and node-negative cases.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.005
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