Concise Review: Vascular Stem Cells and Tumor Angiogenesis
2011
Vascular Stem Cells and Tumor Angiogenesis
publication
Evidence: moderate
Author Information
Author(s): Juan M Melero-Martin, Andrew C Dudley
Primary Institution: Children's Hospital Boston
Hypothesis
The review explores the roles of nontumor-forming vascular stem cells in tumor growth and angiogenesis.
Conclusion
Solid tumors may be driven by both cancer stem cells and nontumor-forming progenitors that contribute to the formation of tumor blood vessels.
Supporting Evidence
- Adult stem cells in tumors do not form tumors but may help cancer cells grow.
- Different types of stem cells can influence how tumors develop and spread.
- Some stem cells can turn into blood vessel cells, which are important for tumor growth.
Takeaway
Some cells in tumors help them grow and make new blood vessels, but not all of these cells cause tumors themselves.
Limitations
The review does not provide experimental data but discusses existing literature.
Digital Object Identifier (DOI)
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