Genetic Analysis of Maximum Drinks Phenotype
Author Information
Author(s): Saccone Scott F, Saccone Nancy L, Neuman Rosalind J, Rice John P
Primary Institution: Washington University School of Medicine
Hypothesis
Can genetic factors influence the maximum number of drinks consumed in a 24-hour period?
Conclusion
The study found that chromosomes 2 and 7 may contain genetic loci that influence maximum drinks consumption, with stronger evidence for chromosome 7.
Supporting Evidence
- Linkage to chromosomes 2 and 7 was detected.
- Multiple trait-associated SNPs were found in the chromosome 7 linkage region.
- Chromosome 4 showed modest evidence for linkage and association.
Takeaway
Scientists looked at genes to see if they affect how much alcohol people can drink in a day, and they found some important clues on two specific chromosomes.
Methodology
The study used a two-stage method involving linkage analysis followed by association analysis on SNP data.
Limitations
Some families were dropped from the analysis due to computer memory constraints, which may affect the results.
Participant Demographics
The study included 1,614 individuals, with 1,388 reporting their maximum drinks.
Statistical Information
P-Value
0.003
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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