Catalase and Its Role in Systemic Lupus Erythematosus
Author Information
Author(s): Anil D'souza, Biji Kurien, Rosalie Rodgers, Jaideep Shenoi, Sadamu Kurono, Hiroyuki Matsumoto, Kenneth Hensley, Swapan K Nath, R Hal Scofield
Primary Institution: Oklahoma Medical Research Foundation
Hypothesis
Specific HNE-protein adducts would be present in SLE red blood cell membranes.
Conclusion
Catalase is modified due to oxidative stress in SLE patients, but it is not a susceptibility gene for the disease.
Supporting Evidence
- Catalase was identified as a target of HNE modification in SLE patients.
- The study found no significant genetic association between the catalase polymorphism and SLE.
- Oxidative stress may lead to lower catalase activity in SLE patients.
Takeaway
The study looked at a protein called catalase in people with lupus and found it gets damaged by stress in the body, but it doesn't cause lupus.
Methodology
The study used mass spectrometry to identify proteins modified by HNE and genotyping to analyze a specific polymorphism in the catalase gene.
Limitations
The study had a small sample size and focused only on African-American families.
Participant Demographics
Participants included 48 pedigrees with African American ancestry.
Statistical Information
Statistical Significance
p > 0.05
Digital Object Identifier (DOI)
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