Study of Genetic Variants Linked to Heart Attacks
Author Information
Author(s): Dov Shiffman, John P. Kane, Judy Z. Louie, Andre R. Arellano, David A. Ross, Joseph J. Catanese, Mary J. Malloy, Stephen G. Ellis, James J. Devlin
Primary Institution: Celera, Alameda, California, United States of America
Hypothesis
Can we identify SNPs associated with myocardial infarction (MI) by investigating approximately 17,000 SNPs?
Conclusion
The study identified 5 SNPs in 4 genes that are likely associated with myocardial infarction.
Supporting Evidence
- 1,949 SNPs were associated with MI in the first study.
- 24 SNPs were confirmed in the second study.
- 5 SNPs in 4 genes were associated with MI in the third study.
- The false discovery rate for the identified SNPs was 0.23.
- The study included a large sample size of 1,816 participants.
Takeaway
The researchers looked at many tiny changes in genes to see if they could find links to heart attacks, and they found 5 important ones.
Methodology
The study used three case-control studies to test the association of SNPs with myocardial infarction.
Potential Biases
Potential for false positive associations due to the retrospective nature of the studies.
Limitations
The study did not include fatal cases of MI and had differences in participant recruitment across studies.
Participant Demographics
Participants were primarily Caucasian, with a mix of cases and controls across three studies.
Statistical Information
P-Value
<0.001
Confidence Interval
90% CI for odds ratios provided in the results
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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