Erythromycin vs Azithromycin for Chlamydia in Pregnancy
Author Information
Author(s): Marc F. Rosenn, George A. Macones, Neil S. Silverman
Primary Institution: Thomas Jefferson University
Hypothesis
Is azithromycin more effective and better tolerated than erythromycin for treating chlamydial cervicitis during pregnancy?
Conclusion
Azithromycin is more effective and better tolerated than erythromycin for treating chlamydial cervicitis in pregnancy.
Supporting Evidence
- The cure rate for azithromycin was 91% compared to 77% for erythromycin.
- Gastrointestinal side effects were reported by 45% of erythromycin patients versus 17% of azithromycin patients.
- 100% compliance was observed in the azithromycin group compared to 61% in the erythromycin group.
Takeaway
This study looked at two medicines to treat a common infection in pregnant women. It found that one medicine, azithromycin, works better and has fewer side effects than the other, erythromycin.
Methodology
48 pregnant patients with cervical chlamydial infections were randomly assigned to receive either erythromycin or azithromycin, and treatment efficacy was assessed by follow-up testing.
Potential Biases
The randomization process was not blinded to the clinic staff involved in patient enrollment.
Limitations
The study had a small sample size, which may limit the ability to detect meaningful differences.
Participant Demographics
Mean age was 19.8 years for erythromycin and 21.3 years for azithromycin; no significant differences in demographics were noted.
Statistical Information
P-Value
0.002
Statistical Significance
p<0.05
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