Efficacy of Antimalarial Treatment in Guinea
Author Information
Author(s): Maryline Bonnet, Cally Roper, Martine Félix, Léonie Coulibaly, Gabriel Mufuta Kankolongo, Jean Paul Guthmann
Primary Institution: Epicentre, Paris, France
Hypothesis
What is the efficacy of two artemisinin combination therapies in treating malaria in Guinea?
Conclusion
Both AS/AQ and AS/SP are highly efficacious in Dabola, while there is evidence of established SP resistance in Laine.
Supporting Evidence
- 220 children were included in the study.
- After 28 days, the failure rate was 1.0% for both AS/AQ and AS/SP.
- 85.6% of patients in the refugee camp had dhfr mutations associated with SP resistance.
Takeaway
The study tested two malaria treatments on children in Guinea and found both worked well, but one area showed resistance to one of the treatments.
Methodology
Children aged 6-59 months with falciparum malaria were randomized to receive either AS/AQ or AS/SP, and efficacy was assessed over 28 days.
Potential Biases
Potential bias due to the non-randomized allocation of treatment groups.
Limitations
The results may not be applicable to the entire country due to local variations in malaria transmission and treatment practices.
Participant Demographics
Children aged 6-59 months with confirmed P. falciparum mono-infection.
Statistical Information
P-Value
0.41
Confidence Interval
95%CI 0–5.3 for AS/AQ and 95%CI 0–5.5 for AS/SP
Statistical Significance
p = 0.41
Digital Object Identifier (DOI)
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