Emerging Role of Gut Microbiota in Breast Cancer Development and Its Implications in Treatment
2024

The Role of Gut Microbiota in Breast Cancer

publication Evidence: moderate

Author Information

Author(s): Mir Rashid, Albarqi Shrooq A., Albalawi Wed, Alatwi Hanan E., Alatawy Marfat, Bedaiwi Ruqaiah I., Almotairi Reema, Husain Eram, Zubair Mohammad, Alanazi Ghaida, Alsubaie Shouq S., Alghabban Razan I., Alfifi Khalid A., Bashir Shabnam

Primary Institution: University of Tabuk, Tabuk, Saudi Arabia

Hypothesis

The gut microbiota may significantly impact breast cancer risk through various mechanisms.

Conclusion

The review highlights the potential of gut microbiota in influencing breast cancer risk and treatment outcomes.

Supporting Evidence

  • The gut microbiota can modulate the immune response, which is critical in cancer development.
  • Dysbiosis in the gut microbiota may influence hormone metabolism and breast cancer risk.
  • Certain gut bacteria are involved in estrogen metabolism, potentially affecting breast cancer progression.
  • Probiotics may help in the prevention and treatment of breast cancer by restoring gut microbiota balance.
  • Research indicates a connection between gut microbiota composition and responses to cancer therapies.

Takeaway

There are tiny bacteria in our stomachs that can affect how likely someone is to get breast cancer and how well treatments work.

Methodology

The review synthesizes existing research on the relationship between gut microbiota and breast cancer.

Limitations

The review does not present new experimental data and relies on existing literature.

Digital Object Identifier (DOI)

10.3390/metabo14120683

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