Genetic Variants in Serotonin Receptor Genes and Substance Use Disorders
Author Information
Author(s): Laith Al-Eitan, Hana Abu Kharmah, Mansour Alghamdi
Primary Institution: Jordan University of Science and Technology
Hypothesis
This study investigates the association between polymorphisms in serotonin receptor genes and substance use disorders in Jordanian males.
Conclusion
Genetic variants of serotonin receptor genes may influence individual susceptibility to substance use disorders in Jordan.
Supporting Evidence
- An allelic association was found between rs9567735 in the HTR2A gene and SUD.
- Haplotype analysis showed significant associations with SUD risk.
- Motives for substance use were correlated with specific SNPs.
Takeaway
The study found that certain genes related to serotonin might make some people more likely to have problems with drugs.
Methodology
The study involved sequencing genotypes in 496 substance use disorder patients and 496 healthy controls.
Potential Biases
Cultural sensitivities and stigma may have affected female participation in the study.
Limitations
The study primarily included male participants, which may not represent the entire community of drug users in Jordan.
Participant Demographics
All participants were Jordanian males, with a mean age of 29 years.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website