D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease
Author Information
Author(s): Lim Soyeon, Chesser Adrianne S., Grima Jonathan C., Rappold Phillip M., Blum David, Przedborski Serge, Tieu Kim
Primary Institution: University of Rochester
Hypothesis
D-β-hydroxybutyrate (DβHB) may confer neuroprotection in Huntington's disease models.
Conclusion
DβHB shows potential as a therapeutic agent for Huntington's disease by improving motor function and extending lifespan in mouse models.
Supporting Evidence
- DβHB infusion improved motor function in mice treated with 3-NP.
- DβHB extended the lifespan of transgenic R6/2 mice.
- DβHB prevented histone deacetylation in cell models expressing mutant huntingtin.
Takeaway
D-β-hydroxybutyrate is like a special fuel that helps protect the brain in mice with a disease called Huntington's.
Methodology
Mice were treated with DβHB and assessed for motor deficits and survival in both toxic and genetic models of Huntington's disease.
Limitations
The study primarily used mouse models, which may not fully replicate human disease.
Participant Demographics
Male C57Bl/6 mice and transgenic R6/2 mice were used.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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