Comparative modelling techniques: where are we?
2003
Comparative Modelling Techniques: Where Are We?
Sample size: 265
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Anna Tramontano
Primary Institution: University of Rome `La Sapienza'
Conclusion
Recent advances in protein structure prediction methods demonstrate that they are sufficiently mature and robust for practical use in the biological community.
Supporting Evidence
- The CASP experiment has been run every 2 years since 1994 to assess protein structure prediction methods.
- Models are automatically compared with target structures to evaluate their quality.
- Results indicate that most groups can produce models of satisfactory quality for easy and intermediate targets.
Takeaway
Scientists are getting better at predicting how proteins fold and work, which helps in understanding diseases and developing new medicines.
Methodology
The study discusses the assessment of protein structure prediction methods through the CASP experiment, which involves predicting protein structures based on known sequences.
Limitations
The assessment process is complex and cannot visually inspect every model due to the large number of submissions.
Digital Object Identifier (DOI)
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