VEGF Expression in Ovarian Cancer
Author Information
Author(s): Shen G H, Ghazizadeh M, Kawanami O, Shimizu H, Jin E, Araki T, Sugisaki Y
Primary Institution: Nippon Medical School
Hypothesis
The study investigates the relationship between vascular endothelial growth factor (VEGF) expression, microvessel density (MVD), and prognosis in ovarian carcinoma.
Conclusion
High VEGF expression is associated with worse survival outcomes in ovarian cancer patients.
Supporting Evidence
- 31% of borderline tumors had low VEGF expression.
- 48% of malignant tumors had high VEGF expression.
- Patients with high VEGF expression had significantly worse survival outcomes.
Takeaway
This study found that patients with high levels of a protein called VEGF in their ovarian tumors tend to have worse outcomes, which could help doctors identify those who need more aggressive treatment.
Methodology
VEGF expression and microvessel density were assessed in ovarian tumors using immunohistochemistry and correlated with clinicopathologic factors.
Participant Demographics
The study included 94 ovarian tumors: 64 malignant, 13 borderline, and 17 benign.
Statistical Information
P-Value
P = 0.0004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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