Study on the Pain-Relieving and Fever-Reducing Effects of Aspartame
Author Information
Author(s): Pradhan Sapna, Shah U. H., Mathur A., Sharma S.
Primary Institution: Army College of Medical Sciences, Delhi
Hypothesis
Does aspartame have antipyretic and analgesic effects comparable to conventional drugs?
Conclusion
Aspartame has significant antipyretic and analgesic effects in experimental models.
Supporting Evidence
- Aspartame showed a statistically significant antipyretic effect at all doses used.
- Aspartame in doses of 4 and 8 mg/kg showed statistically significant protection against writhing.
- The study found no published reports of aspartame's antipyretic effect in this model.
Takeaway
Aspartame can help reduce fever and pain, similar to some common medications.
Methodology
The study used Wistar rats and mice to evaluate the antipyretic and analgesic effects of aspartame through temperature measurement and writhing episodes.
Limitations
The exact mechanism of aspartame's analgesic action needs further investigation.
Participant Demographics
Albino Wistar rats and adult mice of either sex.
Statistical Information
P-Value
p<0.001 for antipyretic effect; p<0.01 for analgesic effect.
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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