Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation
2008
Etoposide Induces Mitochondrial Biogenesis through ATM Activation
Sample size: 3
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Fu Xuan, Wan Shan Lyu, Yi Lisa Liu, Leroy F. Qi, Haiyan Qi
Primary Institution: UMDNJ-Robert Wood Johnson Medical School
Hypothesis
Etoposide-induced mitochondrial biogenesis is mediated through ATM activation.
Conclusion
Etoposide activates ATM, leading to mitochondrial biogenesis through AMPK activation.
Supporting Evidence
- Etoposide treatment led to an increase in mitochondrial mass and DNA content.
- ATM activation was confirmed by phosphorylation at Ser1981.
- AMPK was activated as indicated by phosphorylation at Thr172.
Takeaway
When cells are damaged by a drug called etoposide, a special protein called ATM helps the cells make more mitochondria, which are like tiny power plants in the cells.
Methodology
The study used human ATM+ and ATM- cell lines treated with etoposide to measure mitochondrial mass and DNA content.
Limitations
The study primarily focused on specific cell lines and may not generalize to all cell types.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website