Factors Influencing Polyspermy in IVF with GnRH Antagonist Protocol
Author Information
Author(s): Wu Qiongyu, He Lina
Primary Institution: Zigong Maternal and Child Health Hospital, Zigong, Sichuan, China
Hypothesis
What factors influence polyspermy in in vitro fertilization using the GnRH antagonist protocol?
Conclusion
LH level on trigger day, the number of follicles between 16 mm and 18 mm, and the number of retrieved oocytes are independent risk factors for polyspermy.
Supporting Evidence
- LH level on trigger day was significantly associated with polyspermy (OR=1.305, P=0.005).
- The number of follicles ≥16 mm but <18 mm was significantly associated with polyspermy (OR=1.235, P=0.002).
- The number of retrieved oocytes was significantly associated with polyspermy (OR=1.101, P<0.001).
Takeaway
This study found that certain hormone levels and the number of eggs retrieved can affect the chances of an egg being fertilized by more than one sperm, which is not good for pregnancy.
Methodology
This retrospective case-control study analyzed 354 patients who underwent conventional IVF with a GnRH antagonist protocol, comparing baseline characteristics and clinical data between groups based on polyspermy occurrence.
Potential Biases
Being a retrospective analysis, there may be inherent biases in patient selection and data collection.
Limitations
The study is retrospective and may have baseline imbalances among patients, and some potential confounders may have been overlooked.
Participant Demographics
The study included 354 patients, with 198 in the normal fertilization group and 156 in the polyspermy group.
Statistical Information
P-Value
0.005, 0.002, <0.001
Confidence Interval
1.082-1.574, 1.081-1.412, 1.054-1.150
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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