Acute Phase Reaction During Chemotherapy in Small Cell Lung Cancer
Author Information
Author(s): R. Milroy, D. Shapiro, A. Shenkin, S.W. Banham
Primary Institution: Royal Infirmary, Glasgow
Hypothesis
In patients with chemosensitive tumours, treatment might result in tumour necrosis which would induce an acute phase reaction that could be quantified by serial measurement of CRP concentrations.
Conclusion
The study found a quantifiable acute phase response during chemotherapy for small cell lung cancer, which may help predict chemoresponse.
Supporting Evidence
- Baseline CRP concentrations were raised in 16 of 20 patients.
- CRP levels more than doubled in 11 of 20 patients during induction chemotherapy.
- Seven of the 10 chemosensitive patients showed an acute phase reaction.
Takeaway
When patients with small cell lung cancer get chemotherapy, their body produces a substance called CRP that can help doctors see if the treatment is working.
Methodology
CRP levels were measured in blood samples before and during chemotherapy in patients with small cell lung cancer.
Limitations
The study had a small sample size and included only patients with small cell lung cancer.
Participant Demographics
20 patients with histologically proven small cell lung cancer, 15 with limited disease and 5 with extensive disease.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
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