MMP16 Gene Polymorphisms and Bronchopulmonary Dysplasia
Author Information
Author(s): Hadchouel Alice, Decobert Fabrice, Franco-Montoya Marie-Laure, Halphen Isabelle, Jarreau Pierre-Henri, Boucherat Olivier, Martin Emmanuel, Benachi Alexandra, Amselem Serge, Bourbon Jacques, Danan Claude, Delacourt Christophe
Primary Institution: INSERM, Unité 841, IMRB, Créteil, France
Hypothesis
Polymorphisms in MMP genes might affect MMP function in preterm lungs and thus influence the risk of bronchopulmonary dysplasia (BPD).
Conclusion
MMP16 polymorphisms appear to influence the risk of BPD in premature infants.
Supporting Evidence
- The TT genotype of MMP16 C/T and the GG genotype of MMP16 A/G were found to protect from BPD.
- These genotypes were associated with a smaller active fraction of MMP2.
- MMP16 expression increased during the alveolar stage of lung development.
- Lower MMP16 levels were observed in newborn rat models of arrested alveolarization.
- Genetic factors were shown to account for 53% of the variance in the risk of BPD.
Takeaway
This study found that certain gene variations in MMP16 can help protect premature babies from a serious lung condition called bronchopulmonary dysplasia.
Methodology
The study included 284 neonates with a gestational age of <28 weeks and analyzed nine SNPs in the MMP2, MMP14, and MMP16 genes.
Potential Biases
Potential biases may arise from the heterogeneous management of preterm infants across different neonatal intensive care units.
Limitations
The study was limited to a specific population of premature infants and may not be generalizable to all infants.
Participant Demographics
The study involved 284 neonates, all inborn, with a mean gestational age of 26.4 weeks and a mean birth weight of 838 grams.
Statistical Information
P-Value
p<0.01 for MMP16 C/T and p<0.03 for MMP16 A/G genotypes associated with lower risk of BPD.
Confidence Interval
95% CI for birth weight adjustment: 0.993–0.998
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website