14-3-3σ as a Prognostic Biomarker in Gastric Cancer
Author Information
Author(s): Zhou Wei-hua, Tang Fang, Xu Jie, Wu Xing, Feng Zhi-ying, Li Hai-gang, Lin Dong-jun, Shao Chun-kui, Liu Quentin
Primary Institution: Sun Yat-Sen University
Hypothesis
The expression dynamics of 14-3-3σ and its prognostic significance in gastric cancer are investigated.
Conclusion
High expression of 14-3-3σ is associated with poorer survival outcomes in gastric cancer patients.
Supporting Evidence
- High expression of 14-3-3σ was significantly correlated with clinical stage and tumor invasion.
- Elevated 14-3-3σ expression predicted poorer overall survival and progression-free survival.
- 14-3-3σ expression was an independent prognostic parameter in gastric cancer.
Takeaway
This study found that a protein called 14-3-3σ is found in higher amounts in stomach cancer, and having more of it means patients might not live as long.
Methodology
Immunohistochemistry and Western blot were used to analyze 14-3-3σ expression in gastric cancer tissues, with ROC curve analysis for cutoff score determination.
Potential Biases
Potential biases in patient selection and retrospective analysis.
Limitations
The study was limited to a specific cohort of gastric cancer patients and may not generalize to all populations.
Participant Demographics
105 male and 47 female patients with a median age of 58 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, 2.274-9.012
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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