Antidiabetic Properties of Azadirachta indica and Bougainvillea spectabilis
Author Information
Author(s): Menakshi Bhat, Kothiwale Sandeepkumar K., Tirmale Amruta R., Bhargava Shobha Y., Joshi Bimba N.
Primary Institution: Institute of Bioinformatics and Biotechnology, India
Hypothesis
The study investigates the antidiabetic properties of different extracts of Azadirachta indica and Bougainvillea spectabilis in a murine diabetes model.
Conclusion
The study found that extracts from Azadirachta indica and Bougainvillea spectabilis can significantly improve glucose tolerance and insulin production in diabetic mice.
Supporting Evidence
- A. indica chloroform extract and B. spectabilis aqueous and methanolic extracts showed good oral glucose tolerance.
- After 21 days of treatment, there was a significant increase in glucose-6-phosphate dehydrogenase activity.
- Immunohistochemical analysis showed regeneration of insulin-producing cells with the treatment.
- Plasma insulin and c-peptide levels normalized after treatment with the extracts.
Takeaway
This study shows that two plants, Azadirachta indica and Bougainvillea spectabilis, can help lower blood sugar and improve insulin levels in mice with diabetes.
Methodology
The study used a streptozotocin-induced diabetic murine model to test the effects of various extracts of the plants on biochemical parameters related to diabetes.
Limitations
The study was conducted on a small sample size of mice and may not fully represent human responses.
Participant Demographics
Swiss mice, 6-8 weeks old, weighing 25±2g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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