Thrombophilia and Adverse Pregnancy Outcomes in Pregnant Women
Author Information
Author(s): Sara Sedano-Balbás, Mark Lyons, Brendan Cleary, Margaret Murray, Geraldine Gaffney, Majella Maher
Primary Institution: National University of Ireland, Galway
Hypothesis
Is there a correlation between acquired activated protein C resistance (APCR) and adverse pregnancy outcomes?
Conclusion
The study found that while thrombophilic mutations are common in pregnant women with acquired APCR, they do not appear to significantly increase the risk of severe adverse pregnancy outcomes.
Supporting Evidence
- 15.4% of the study cohort was identified as APCR positive.
- Factors V, VIII, and IX levels were significantly higher in the acquired APCR group compared to the control group.
- 92 subjects in the positive APCR group had common thrombophilic mutations.
Takeaway
Pregnant women with certain blood conditions might have a higher chance of complications, but not all of them will have serious problems.
Methodology
The study analyzed blood samples from 907 pregnant women to assess levels of coagulation factors and the presence of thrombophilic mutations.
Potential Biases
The small sample size of negative APCR subjects may lead to nonsignificant differences.
Limitations
The study did not include environmental factors like smoking and BMI that could influence outcomes.
Participant Demographics
{"age_range":"15-42","mean_age":28,"parity":{"primigravida":42.2,"multigravida":57.8}}
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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