The TEAM Trial: Comparing Treatments for Unruptured Intracranial Aneurysms
Author Information
Author(s): Raymond Jean, Molyneux Andrew J, Fox Allan J, Johnston S Claiborne, Collet Jean-Paul, Rouleau Isabelle
Primary Institution: TEAM coordinating centre, Interventional Neuroradiology Research Unit, Department of Radiology, CHUM Notre-Dame Hospital
Hypothesis
Do patients with eligible unruptured aneurysms have a better clinical outcome at 10 years with endovascular or conservative management of their lesions?
Conclusion
The TEAM trial aims to determine whether endovascular treatment is more effective than conservative management for patients with unruptured intracranial aneurysms.
Supporting Evidence
- Endovascular treatment may prevent rupture but involves immediate risks.
- Most aneurysms remain asymptomatic until they rupture.
- The annual risk of bleeding from an unruptured aneurysm is debated but generally low.
Takeaway
This study is trying to find out if treating brain aneurysms right away is better than waiting to see if they cause problems.
Methodology
A randomized, controlled trial comparing conservative management with endovascular treatment in 2002 patients across 60 international centers.
Potential Biases
Potential biases in treatment allocation and patient selection.
Limitations
The study may face challenges in patient recruitment and long-term follow-up.
Participant Demographics
Patients aged 18 or older with at least one documented unruptured intracranial aneurysm.
Statistical Information
P-Value
0.0167
Statistical Significance
p<0.0167
Digital Object Identifier (DOI)
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