Growth Hormone Response and Cardiovascular Risk Factors in Older Adults
Author Information
Author(s): Carmichael John D, Danoff Ann, Milani Daniela, Roubenoff Ronenn, Lesser Martin L, Livote Elayne, Reitz Richard E, Ferris Steven, Kleinberg David L
Primary Institution: New York University School of Medicine
Hypothesis
What is the relationship between growth hormone response to GHRH-arginine and cardiovascular risk factors in healthy adults aged 50-90?
Conclusion
The study found that lower growth hormone peaks are significantly associated with an increasing number of cardiovascular risk factors in healthy older adults.
Supporting Evidence
- GH peaks varied widely, with some individuals showing significantly low levels.
- Fasting glucose, insulin, and BMI were strongly correlated with GH peak levels.
- Subjects with more cardiovascular risk factors had lower GH peaks.
Takeaway
Older adults can have different levels of growth hormone, and those with more health risks tend to have lower levels.
Methodology
The study used a cross-sectional design to assess growth hormone responses to GHRH-arginine in 86 healthy adults aged 50-90, measuring various cardiovascular risk factors.
Limitations
The study does not differentiate whether low growth hormone is a cause or effect of cardiovascular risk factors.
Participant Demographics
57 women and 29 men, aged 50-90, with a mean age of 65.4 years; 82.5% non-Hispanic Caucasian.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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