CTLA-4 Gene Polymorphisms and Primary Sjögren Syndrome
Author Information
Author(s): Gottenberg Jacques-Eric, Loiseau Pascale, Azarian Mariam, Chen Chun, Cagnard Nicolas, Hachulla Eric, Puechal Xavier, Sibilia Jean, Charron Dominique, Mariette Xavier, Miceli-Richard Corinne
Primary Institution: Institut Pour la Santé et la Recherche Médicale (INSERM)
Hypothesis
Are CTLA-4 CT60 and/or +49A/G polymorphisms involved in the genetic predisposition to primary Sjögren syndrome?
Conclusion
The study found no association between CTLA-4 CT60 or +49A/G polymorphisms and primary Sjögren syndrome.
Supporting Evidence
- The CTLA-4 +49A/G*A allele was found on 73% of chromosomes in patients with pSS in the first cohort.
- In the replication cohort, the CTLA-4 +49A/G*A allele was found on 62% of chromosomes in patients with pSS.
- No significant difference in CTLA-4 CT60 allelic or genotypic distribution was observed between patients and controls.
Takeaway
The researchers looked at genes to see if they make people more likely to get a disease called primary Sjögren syndrome, but they found no link.
Methodology
A case-control study analyzing CTLA-4 CT60 and +49A/G polymorphisms in two cohorts of patients with primary Sjögren syndrome and controls.
Potential Biases
Potential sampling bias may have influenced the results.
Limitations
The study may have been affected by sampling bias, which could explain contradictory results in previous studies.
Participant Demographics
Patients were Caucasian, with a mix of autoantibody statuses.
Statistical Information
P-Value
0.036
Confidence Interval
1.02 to 1.95
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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